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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F8
All Species:
16.36
Human Site:
S453
Identified Species:
45
UniProt:
A0AVK6
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A0AVK6
NP_078956.2
867
94166
S453
M
Q
L
E
E
Q
S
S
E
S
R
Q
K
V
K
Chimpanzee
Pan troglodytes
XP_508325
867
94169
S453
M
Q
L
E
E
Q
S
S
E
S
R
Q
K
V
K
Rhesus Macaque
Macaca mulatta
XP_001095088
867
94195
S453
M
Q
L
E
E
Q
S
S
E
S
R
Q
K
V
K
Dog
Lupus familis
XP_534087
864
93661
S453
M
Q
L
E
E
Q
S
S
E
P
R
K
K
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q58FA4
860
93258
Q450
C
K
M
Q
L
E
E
Q
S
S
E
P
R
K
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506156
878
95490
S453
M
Q
L
E
E
Q
S
S
G
P
K
K
M
K
M
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084876
724
79575
K316
K
V
H
V
T
E
E
K
G
R
K
P
A
F
Q
Zebra Danio
Brachydanio rerio
XP_694311
917
100437
A464
K
H
L
D
E
Q
S
A
D
G
R
P
N
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002321561
384
43173
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
96.6
89.6
N.A.
83
N.A.
N.A.
73.8
N.A.
48
39.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
98.1
94.2
N.A.
88.5
N.A.
N.A.
82.1
N.A.
59.9
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
13.3
N.A.
N.A.
53.3
N.A.
0
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
46.6
N.A.
N.A.
66.6
N.A.
20
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
20.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
30.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
0
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
0
0
0
12
0
12
% A
% Cys:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
56
67
23
23
0
45
0
12
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% F
% Gly:
0
0
0
0
0
0
0
0
23
12
0
0
0
0
0
% G
% His:
0
12
12
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
23
12
0
0
0
0
0
12
0
0
23
23
45
23
56
% K
% Leu:
0
0
67
0
12
0
0
0
0
0
0
0
0
0
0
% L
% Met:
56
0
12
0
0
0
0
0
0
0
0
0
12
0
12
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
12
12
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
23
0
34
0
0
0
% P
% Gln:
0
56
0
12
0
67
0
12
0
0
0
34
0
0
12
% Q
% Arg:
0
0
0
0
0
0
0
0
0
12
56
0
12
0
0
% R
% Ser:
0
0
0
0
0
0
67
56
12
45
0
0
0
0
0
% S
% Thr:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
12
0
12
0
0
0
0
0
0
0
0
0
45
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _